Nanomechanics of the Endothelial Glycocalyx
نویسندگان
چکیده
منابع مشابه
Nanomechanics of the Endothelial Glycocalyx in Experimental Sepsis
The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal side of the endothelium, regulates vascular adhesiveness and permeability. Although central to the pathophysiology of vascular barrier dysfunction in sepsis, glycocalyx damage has been generally understudied, in part because of the aberrancy of in vitro preparations and its degradation during tissue handling. The aim...
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High dietary salt (NaCl) is a known risk factor for cardiovascular pathologies and inflammation. High plasma Na+ concentrations (high Na+) have been shown to stiffen the endothelial cortex and decrease nitric oxide (NO) release, a hallmark of endothelial dysfunction. Here we report that chronic high Na+ damages the endothelial glycocalyx (eGC), induces release of inflammatory cytokines from the...
متن کاملThe endothelial glycocalyx
Once thought to be a structure of small size and uncertain significance, the endothelial glycocalyx is now known to be an important regulator of endothelial function. Studies of the systemic vasculature have demonstrated that the glycocalyx forms a substantial in vivo endothelial surface layer (ESL) critical to inflammation, barrier function, and mechanotransduction. The pulmonary ESL is signif...
متن کاملThe Endothelial Glycocalyx Promotes Homogenous Blood Flow
P. Mason McClatchey, Michal Schafer, Kendall S. Hunter, Jane E. B. Reusch 5 6 7 Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, 8 Colorado USA 9 10 Department of Medicine, Denver VA Medical Center, Denver, Colorado USA 11 12 Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, 13 Colorado USA 14 15 Division of Cardiology, Depar...
متن کاملEndothelial Glycocalyx and Cardiopulmonary Bypass.
On the outer surface of a human cell there is a dense layer of complex carbohydrates called glycocalyx, also referred to as glycans or the sugar coating on the cell surface, which is composed of a complex array of oligosaccharide and polysaccharide glucose chains that are covalently bonded to proteoglycans and lipids bound to the cell membrane surface. Studies of an intact endothelial glycocaly...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2020
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2019.07.021